According to a new research, dipeptides containing 2-oxo-imidazole (2-oxo-IDPs) have extremely significant antioxidant activity. A technique has also been developed to specifically detect very minute concentrations of 2-oxo-IDPs. And discovered for the first time that several forms of 2-oxo-IDPs are contained in meat, including beef, pork, and chicken.
Imidazole dipeptides (IDPs), which are abundant in meat and fish, are substances produced in the bodies of various animals, including humans, and have been reported to be effective in relieving fatigue and preventing dementia. However, the physiological mechanism by which IDPs exhibit these activities had not been determined previously. A research team, led by Professor Hideshi Ihara from the Osaka Metropolitan University Graduate School of Science, was the first to discover 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs) — which have one more oxygen atom than normal IDPs — and found that they are the most common variety of IDPs derivatives in the body. The researchers also found that they have remarkably high antioxidant activity.
In their study, the researchers established a method for selective and highly sensitive detection of five types of 2-oxo-IDPs using mass spectrometry, which enables quantitative detection of trace 2-oxo-IDPs in living organisms. Using this method, they revealed for the first time that beef, pork, chicken, and other meats contain antioxidants, not only IDPs but a variety of different 2-oxo-IDPs. Their findings were published in Antioxidants.
