In a world-first study of 390,435 people, University of South Australia researchers found causal genetic evidence that cardio health – as reflected in blood pressure and heart rate – influences coffee consumption.
Conducted in partnership with the SAHMRI, the team found that people with high blood pressure, angina, and arrythmia were more likely to drink less coffee, decaffeinated coffee or avoid coffee altogether compared to those without such symptoms and that this was based on genetics. Lead researcher and Director of UniSA’s Australian Centre for Precision Health, Professor Elina Hypponen says it’s a positive finding that shows our genetics actively regulate the amount of coffee we drink and protect us from consuming too much.
“People drink coffee for all sorts of reasons – as a pick me up when they’re feeling tired, because it tastes good, or simply because it’s part of their daily routine,” says Prof Hypponen. She adds, “But what we don’t recognise is that people subconsciously self-regulate safe levels of caffeine based on how high their blood pressure is, and this is likely a result of a protective genetic mechanism. What this means is that someone who drinks a lot of coffee is likely more genetically tolerant of caffeine, as compared to someone who drinks very little. Conversely, a non-coffee drinker, or someone who drinks decaffeinated coffee, is more likely prone to the adverse effects of caffeine, and more susceptible to high blood pressure.”
In Australia, one in four men, and one in five women suffer from high blood pressure, with the condition being a risk factor for many chronic health conditions including stroke, heart failure and chronic kidney disease.
Using data from the UK Biobank, researchers examined the habitual coffee consumption of 390,435 people, comparing this with baseline levels of systolic and diastolic blood pressure, and baseline heart rate. Causal relationships were determined via Mendelian randomisation.
Prof Hypponen says, “Whether we drink a lot of coffee, a little, or avoid it altogether, this study shows that genetics are guiding our decisions to protect our cardio health.” WITH ANI INPUTS
